399 Lafayette Street at East 4th Street
All's I knows is when I needs a bottle of somethin'-somethin' this is the place to go. It's nice, spacious, and approachable--kind of like a Barnes & Noble for wines and spirits, with staff recommendations and everything. The store is very well-organized and laid out, which makes it easy for you to find sakes, dessert wines, champagne, whiskeys, mixers, or whatever it is that you may need for that dinner party you're running off to. Apparently, it's also New York City's largest online wines and spirits retailer, although, luckily for me, a wine run is just around the corner.